President Miguel Diaz-Canel said many are feared dead according to Sky News.
The plane came down shortly after take-off and exploded on the "highway" between Boyeros and Havana near the Jose Marti International Airport here Radio Habana Cuba tweeted.
Fire crews and ambulances were at the scene BBC reported.
The plane reportedly belongs to Cubana de Aviacion. The flight was headed to Guyana an airport source told CNN.
--IANS him/nir
